SANTYL Compatibility

Previous studies have shown17, 22 the positive outcomes when using SANTYL Ointment in conjunction with other wound care products. To ensure that the collagenase enzyme in SANTYL maintains activity, in vitro testing was performed across a wide variety of commonly used products to determine compatibility. Testing did not evaluate efficacy, only the ability of collagenase to remain active and functional.

An inhibition level of 20% or less is deemed an acceptable threshold for enzymatic activity when used concomitantly with topical adjunctive therapies.30

If inhibition levels exceed 20%, collagenase enzyme activity and efficacy may be affected.

These results are from in vitro studies and are only an approximation of actual therapeutic outcomes. The decision to use a wound care product or combination of products should rest on a clinical judgement in which the perceived benefits outweigh any potential risks.

For detailed product information, including indications for use, contraindications, effects, precautions, warnings, and important safety information, please consult each product's Instructions for Use (IFU) prior to use.

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Type of Product

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Silver Dressings
ACTICOAT♢52.4Nanocrystalline silver
Actisorb™ Ag0.0Silver charcoal-activated dressing
Algicell®<2.0Silver dispersed in calcium alginate fibers
Algidex® Ag3.81Ionic silver alginate wound dressing
ALLEVYN♢ Ag7.6Ionic silver urethane wound dressing
ALLEVYN♢ Ag+0.0Ionic silver urethane wound dressing
Aquacel® Ag7.7Hydrofiber silver dressing
Aquacel® Ag Extra20Hydrofiber® Technology dressing with silver
Aquacel® Ag Advantage0.0Silver dispersed in Alginate Fibers
Argentyn-23®0.4Colloidal Silver
Arglaes®63.8Silver dispersed in alginate powder
Biatain® Ag<1.0Hydro-activated silver in soft dressing
BIOSTEP♢ Collagen Matrix Dressing36.7Silver dispersed in collagen matrix
Calcium Alginate Dressing with Silver0.0Gelling fiber silver dressing with NaHZrPO4
ColActive + Ag34.7Collagen matrix dressing with silver
DermaGinate® Ag30.0Silver dispersed in alginate fibers
DURAFIBER♢ Ag Gelling Fiber Dressing0.4Cellulose-based dressing
DynaGinate™ Ag5.0Silver dispersed in Alginate Fibers
Elta® SilverGel™12.4Proprietary silver gel
ExcelGinate® Ag11.0Ionic silver in alginate fibers
Gentell® Ag84.0Calcium Alginate fibers with silver
Granufoam® Ag0.0Silver dispersed in a polyurethane foam
Keracel® Ag15.4Gelling fiber silver dressing
KerraContactTM Ag80.0Silver with Oxysalts
Maxorb® Ag18.0Ionic silver alginate wound dressing
Melgisorb®22.8Silver dispersed in alginate fibers
Mepilex® Ag15.7Ionic silver silicone dressing
Normlgel® Ag100.0Silver dispersed in hydrogel
NovaGranTMBlue50.0Silver in a foam with Methylene Blue and Gentian Violet
Opticell Ag81.0Chitosan fibers with silver
Optifoam® Ag0.0Ionic silver
PolyMem® Ag1.0Nanocrystalline silver
Puracol® Ag24.8Collagen-based dressing
Reinforced gelling fiber Ag78.0Silver in alginate and guluronic acid
ReliaMed® Ag23.0Silver dispersed in alginate fibers
RestaTM SilverGel®37.0Crystal-clear antimicrobial silver gel
Restore® Calcium Alginate9.0Silver dispersed in calcium alginate fibers
Restore® TRIACT™ Silver0.0Silver sulfate dressing
Silvadene® (1%)67.01% silver sulfadiazine in cream base
SilvaKollagen® Gel19.8Hydrolysate of collagen with silver oxide
Silvasorb®25.0Ionic silver
Silvercel™<10.0Silver dispersed in alginate fibers
Silver Sol Gel>95.0Cosmetic gel
Silverlon®44.3Elemental silver
SilverMed™10.8Microparticulate silver in carbomer gel
Sorbalgon® Ag4.4Silver containing calcium alginate dressing
Tegaderm™ Ag24.0Silver sulfate dressing
Tender Calginate™ Silver0.0Silver dispersed in Alginate Fibers
TheraBond® Ag20.9Ionic silver in fiber dressing
TRITEC™ Ag13.0Silver dispersed in fibers
UrgoTul™ Ag100.0Silver dispersed in polyester mesh
Wound Cleansers
3M™ Wound Cleanser76.2Pyridoxine and Zn-salts—based cleanser
Allclenz®68.8Amphotheric surfactant-based cleanser
Aloe Vesta®100.0Anionic and amphotheric surfactants-based cleanser
Anasept® Spray0.0Sodium hypochlorite-based cleanser
Biolex™0.0Poloxamine-908 and Potassium sorbate-based cleanser
CarraKlenz™100.0Anionic surfactant-based cleanser
Clorpactin®20.9Hypochlorite-based cleanser
Coloplast Bedside-Care® Shampoo72.7Benzethonium chloride-based cleanser
Dakin's Solution® (4X diluted)0.0Sodium hypochlorite-based cleanser
Dermagran®70.0Pyridoxine and Zn-salts—based cleanser
DermaKlenz™84.3Pyridoxine HCl and alcohol-based cleanser
DERMAL WOUND CLEANSER52.0Non-ionic surfactant and EDTA-based cleanser with benzethonium chloride
Dermal Wound Cleanser40.0EDTA, Amphotheric surfactants
Gentell® Wound Cleanser63.0Amphotheric surfactant-based cleanser
HIBICLENS®>95.0CHG and isopropanol-based cleanser
Lactated Ringers Solution pH 6.725.0Sodium lactate-based cleanser
Microcyn® Rx Skin and Wound HydroGel0.0Sodium hypochlorite-based cleanser
Microcyn® Rx Wound Care Spray0.0Sodium hypochlorite-based cleanser
MicroKlenz™100.0Amphotheric surfactant-based cleanser with benzethonium chloride
MPM Wound Cleanser100.0Benzethonium chloride-based cleanser
PeleVerus®32.0Non-ionic surfactant and zinc-salts—based cleanser
Puracyn® Plus0.0Hypochlorous acid (HOCl) in water
Pure&Clean® Wound Cleanser0.0Hypochlorous Acid (HOCl) in water
Remedy®89.0Anionic surfactant-based cleanser
REPARA®20.0Amphotheric surfactant-based cleanser
Restore®35.18Poloxamer-188 and alkyl paraben-based cleanser
SAF-Clens® AF77.7Amphotheric surfactant-based cleanser
Sea Clens®42.0Non-ionic surfactant and EDTA-based cleanser
Shur-Clens®0.0Poloxamer-188—based cleanser
Skintegrity®70.0Amphotheric surfactant and EDTA-based cleanser
Soothe & Cool® Cleanse100.0EDTA, cationic- and amphotheric-based cleanser
UltraKlenz™100.0EDTA, non-ionic surfactants
VASHE® Wound Solution0.0Hypochlorite-based cleanser
Viniferamine®27.5Benzalkonium chloride-based cleanser
Wound Dressings
ADAPTIC™5.4Non-adhering dressing
ALGISITE♢ M0.0Calcium-alginate dressing
ALLEVYN♢0.0Hydrocellular dressing
AMERIGEL®0.0Hydrogel dressing
Aquasorb®0.0Hydrogel-polyurethane dressing
Bassa-Gel™0.0PEG-based hydrogel for wound coverage
Biatain®1.3Soft dressing
Bismuth Formic Iodide (BFI)75.9BFI in talc powder base
BlastX™ Antimicrobial Wound Gel5.1Benzalkonium chloride in PEG
Carrasyn® Hydrogel0.0Carbopol-based hydrogel
ColActive® Plus0.0Collagen-based dressing
Covaderm®0.0Absorbent-adhesive dressing
Curasol™0.0Hydrogel dressing
Cutimed® Sorbact®0.0Super absorbent dressing
Derma Collagen20Collagen based dressing
Dermaginate™0.0Calcium alginate-based dressing
Drawtex®0.0Hydroconductive dressing
DuoDERM®22.0CGF dressing
DURAFIBER♢ Ag Gelling Fiber Dressing0.0Cellulose-based dressing
Endoform™0Extracellular matrix (ECM) product
Endoform (Natural Dermal Template)1.3Collagen matrix with glycosaminoglycans and adhesive proteins
Enluxtra™30.0Super absorbent hydrofiber dressing
Exufiber®0.0PVA fibers
Fibracol™2.7Collagen-based alginate dressing
GlucanPro® Cream 300069.0Petrolatum-based dressing
Hydrofera®0.0Dye-containing bacteriostatic dressing
INTRASITE♢ Gel0.0Cellulose-based hydrogel
McKesson Antimicrobial HydroGel69.6Hypochlorous Acid (HOCl) in water + LiMgNa Silicate
Medihoney®22.3Leptospermum honey dressing
Mepilex®10.4Soft silicone foam dressing
Mesalt®0.0Salt-releasing wound dressing
Multidex® Gel<5.0Maltodextrin gel dressing
Multipad™0.0Non-adherent dressing
Normgel®39.0Hydrogel dressing
OASIS®6.1SIS product
Opticell0Fiber dressing
Plurogel®0Poloxamer and phenoxyethanol gel
PROMOGRAN PRISMA™ Matrix35.6Collagen-based dressing
Procellera®5.8Wound dressing
Promogran™22.5Collagen-based dressing
Prontosan® Gel (10%)96.5PHMB-containing gel
PROSHIELD♢0.0PEG-based semi-solid dressing
Regenecare®100Lidocaine Hydrogel
RTD™ Dressing0.0MB, GV, and Ag+ in fiber dressing
SAF-Gel®2.00Hydrogel dressing
Simpurity™0.0Alginate wound dressing
Skintegrity® Hydrogel100.0Hydrogel dressing
Sofsorb®0.0Super absorbent dressing
SOLOSITE♢ Gel8.0Hydrogel dressing
Sorbalgon®15.5Calcium alginate dressing
TheraHoney®0.0Medicinal honey dressing
Theraworx®50Magnesium Sulfate Attenuator HPUS
Transeal®0.0Transparent film dressing (polyurethane)
UrgoTul™65.0Polyester mesh
Viscopaste®0.0ZnO based cream impregnated into the gauze
Xeroform™0.0Bismuth in petrolatum gauze
Iodine Dressings
IODOFLEX♢93.8Iodine dressing
IodoFoam®2.8Complexed iodine in foam dressing
Iodoform1.6Iodoform-impregnated gauze
IODOSORB♢87.0Iodine gel
Antibacterials
Bacitracin0Antibacterial active
Benzalkonium chloride99.0Cationic surfactant antimicrobial
Benzethonium chloride<95.0Cationic surfactant antimicrobial
Bismuth tribromophenate0.0Bismuth-based antimicrobial
Brilliant green20.0Antibacterial active
CaSO4 powder6.0Antibacterial carrier
Chlorhexidine gluconate0.0Biguanide-based antimicrobial
Colistin sulfate powder0.0Peptide-based antibacterial
Cyclosporine A powder0.0Anti-inflammatory agent
Dapsone powder0.0Sulfone-based antibacterial
Gentamicin sulfate powder9.8Carbohydrate-based antimicrobial
Mafenide acetate powder0.0Sulfonamide-based antimicrobial
Metronidazole powder100.0Antifungal agent
Mupirocin powder0.0Carbohydrate-based antimicrobial
Neomycin powder0.0Carbohydrate-based antimicrobial
pDADMAC (from Bioguard® gauze)0.0Bacteriostatic polymer
pDADMAC (neat) powder<10.0Bacteriostatic polymer
Penicillin35.0beta-lactam antibiotics
Polyhexamethylene biguanide (PHMB) powder91.0Biguanide-based antimicrobial
Polysporine®1.2Protein antimicrobial mixture
Silver sulfadiazine51.0Silver-containing antimicrobial
Unasyn® powder25.0Antibacterial powder
Antibacterial Dressings
ALTABAX®20.0Antibacterial cream
Anasept® Gel83.0Wound dressing
Bactroban® Cream0.0Antibacterial cream
BACTIGRAS♢0.0Parafin dressing
Cephalexin15.5Antibacterial formulations (tablets)
Ciprofloxacin (tablets and ophthalmic solution)100.0Antibacterial formulations (tablets or ophthalmic solution)
Clindamycin Phosphate Gel0.0Antibacterial hydrogel
Cutimed® Sorbact®0.0Bacteriostatic gauze
Doxycycline100.0Antibacterial capsules
Gentamicin Sulfate Ointment USP, 0.1%13.0Antibacterial (Oil-based), Fougera®
Kerlix® Gauze (PHMB)100.0Bacteriostatic gauze
Levofloxacin100.0Antibacterial formulations (tablets)
Metronidazole (Flagyl)100.0Antiprotozoal
Nitrofurantoin60.0Antibacterial capsules
Sulfamylon® Cream0.0Antibacterial cream
Vancomycine powder68.9Antibacterial powder
Zovirax®0.0Antibacterial cream
Other Products
Americaine® Spray<2.0Benzocaine as an active analgesic in spray base
Amphotericin B powder85.0Antifungal powder
Benzocaine15.0Analgesics active
Cell power100.0Dissolved oxygen with minerals
Clobetasol propionate0.0Anti-inflammatory cream
Clotrimazole11.0Antifungal cream
Cyclosporine A0.0Anti-inflammatory agent
Dexamethasone0.0Antiinflammatory Agent
Diltiazem HCl0 
EMLA®0.0Mixture of lidocaine and prilocaine in a cream base
Fluocinonide (Lidex)<5.0Anti-inflammatory cream
Gabapentin (tablets 400mg)16.3Pain relief tablets
Lidocaine (1%) powder13.0Powder
Lidocaine (5%) ointment37.5Pain relief ointment
Miconazole nitrate powder70.0Antifungal powder
Mycophenolate mofetyl13.0Anti-inflammatory agent
Neosporin® (Original)0.0Triple Antibiotics in White petrolatum base
Neosporin® (Pain Relief)0.0Triple Antibiotics in White petrolatum base+Pramoxine HCl
Neomycin Trisulfate60.0White to yellow powder; BioReagent Product Line
Nifedipine0.0Calcium blocker and chest pain reliever
Nystatin cream97.8Antifungal cream
Nystatin powder17.2Antifungal powder
Phenytoin (Dilantin)<5.0Seizure control
Sodium thiosulfate0.0NA
Sodium urate<5.0Sodium salt of uric acid
Timolol Maleate 0.5%0.0Ophthalmic agent
Triamcinolone Acetonide0.0Anti-inflammatory cream
Vicodin®63.0Analgesic

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